{"id":24,"date":"2024-06-13T08:53:36","date_gmt":"2024-06-13T06:53:36","guid":{"rendered":"https:\/\/www-2024.biomicrolab.ing.uniroma2.it\/?page_id=24"},"modified":"2026-07-24T14:52:40","modified_gmt":"2026-07-24T12:52:40","slug":"pagina-di-prova","status":"publish","type":"page","link":"https:\/\/biomicrolab.ing.uniroma2.it\/?page_id=24","title":{"rendered":"Research"},"content":{"rendered":"\n

MICROFLUIDIC IMPEDANCE CYTOMETRY (MIC)<\/mark><\/u><\/strong><\/p>\n\n\n\n

Microfluidic impedance cytometry (MIC) is a label-free technique that characterizes individual flowing particles\/cells based on their interaction with a multifrequency electric field. For an introduction you can read our Tutorial Review doi.org\/10.1039\/d0lc00840k<\/a>.<\/mark><\/p>\n\n\n\n

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Improving the technology<\/mark><\/strong><\/p>\n\n\n\n

Over the years, we have developed several techniques to push MIC beyond its limits:<\/mark><\/p>\n\n\n\n

Improving measurement accuracy<\/strong> by compensation of position-induced blurring<\/strong> (e.g., 10.1039\/c6lc01516f<\/a>, 10.1016\/j.snb.2017.03.035<\/a>, 10.1039\/c6lc00339g<\/a>, 10.1016\/j.snb.2017.10.113<\/a>) and coincidence arbitration<\/strong> (10.1109\/TBME.2020.2995364<\/a>).<\/mark><\/p>\n\n\n\n

Enhancing multiparametric characterization<\/strong> capabilities by means of innovative cytometer designs<\/strong>. We enabled impedance-based sensing of cell\/particle trajectory<\/strong> (10.1007\/s10404-018-2055-3<\/a>, 10.1039\/c9lc00071b<\/a>), shape<\/strong> (10.1039\/c4lc00221k<\/a>, 10.1109\/JMEMS.2014.2325979<\/a>, 10.1109\/JMEMS.2010.2067204<\/a>), deformability<\/strong> (10.1109\/TBME.2022.3197214<\/a>, 10.1002\/smll.202570038<\/a>).    <\/mark><\/p>\n\n\n\n

Addressing the longstanding high throughput vs high frequency-resolution<\/strong> challenge, demonstrating fast acquisition of thousands of single-cell impedance spectra at 14-frequencies with unprecedented resolution (10.1016\/j.bios.2026.118757<\/a>).<\/mark><\/p>\n\n\n\n

High-impact applications<\/mark><\/strong><\/p>\n\n\n\n

MIC has been successfully applied in different scenarios including life-science research, diagnostics, and environmental monitoring. Contributions from our group or within joint collaborations include:<\/mark><\/p>\n\n\n\n